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原文标题：Self-Adhesive Silicone Microstructures for the Treatment of Tympanic Membrane Perforations
译文标题：自粘硅胶微结构治疗鼓膜穿孔
原文摘要：
Inspired by the gecko foot, polymeric microstructures have demonstrated reliable dry adhesion to both stiff objects and sensitive surfaces such as skin. Microstructured silicone patches are proposed, herein, for the treatment of tympanic membrane perforations with the aim of serving as an alternative for current surgical procedures that require anesthesia and ear canal packing. Sylgard 184 PDMS micropillars of 20 μm in diameter and 60 μm in length are topped by a Soft Skin Adhesive (SSA) MG7-1010 terminal layer, of about 25 μm thickness. The adhesion is evaluated by specially designed tack tests against explanted murine eardrums and, for comparison, against a rigid substrate. Functional effects are evaluated using auditory brainstem responses (ABRs) and distortion product otoacoustic emissions (DPOAE). The adhesion strength of the microstructure and unstructured controls to explanted murine tympanic membranes is comparable (typically 12 kPa), but the microstructured patches are easier to handle by the surgeon. For the first time, partial recovery of hearing performance is measured immediately after patch application. The novel patches adhere without the need for further fixation, removing the need for ear canal packing. The proposed material design holds great promise for improving clinical treatments of tympanic membrane perforations.
译文摘要：
受到壁虎足的启发，聚合物微结构已经证明了对坚硬物体和敏感表面(如皮肤)的可靠干粘附性。本文提出了微结构硅胶贴片用于鼓膜穿孔的治疗，目的是作为目前需要麻醉和耳道填充的外科手术的替代方案。Sylgard 184 PDMS微柱直径为20 μm，长为60 μm，顶端是厚度约为25 μm的SSA (Soft Skin Adhesive) m7 -1010终端层。粘附性是通过专门设计的对移植的小鼠耳膜的黏附试验来评估的，为了比较，对刚性衬底的黏附。使用听觉脑干反应(ABRs)和失真产物耳声发射(DPOAE)评估功能效应。微结构和非结构对照对移植小鼠鼓膜的粘附强度相当(通常为12kpa)，但微结构贴片更容易由外科医生处理。这是第一次在贴片应用后立即测量听力性能的部分恢复。新型耳贴片不需要进一步固定，无需耳道填塞。所提出的材料设计对改善鼓膜穿孔的临床治疗有很大的希望。
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发表于 2023-1-12 09:10:27
